반응 #2983

반응 방정식

triethylsilane

4-oxo-4-(4-ethylphenyl)butyric acid

→

4-(4-ETHYLPHENYL)BUTYRIC ACID

용매

trifluoroacetic acid

반응 조건

후처리

1. 1
   workup.ADDITIONIt is poured into ice
2. 2
   추출It is extracted with 3 volumes of ether
3. 3
   세척The organic phases are washed 3 times with 10% potassium carbonate solution
4. 4
   workup.ADDITIONby adding concentrated hydrochloric acid until the pH is 3-4
5. 5
   기타The precipitate obtained
6. 6
   기타recrystallized

실험 절차

In a 100-cm3 flask, 2.5 g of 4-oxo-4-(4-ethylphenyl)butyric acid are dissolved with magnetic stirring in 19 cm3 of trifluoroacetic acid. 3.2 g of triethylsilane are added dropwise. The reaction mixture is stirred for 86 hours at room temperature. It is poured into ice. It is extracted with 3 volumes of ether. The organic phases are washed 3 times with 10% potassium carbonate solution. The aqueous phases are combined and then acidified by adding concentrated hydrochloric acid until the pH is 3-4. The precipitate obtained is drained and then recrystallized.

출처