반응 #2982

반응 방정식

hydrochloric acid

ethylbenzene

aluminum chloride

succinic anhydride

→

4-OXO-4-(4-ETHYLPHENYL)BUTYRIC ACID

반응 조건

후처리

1. 1
   온도The solution is cooled in an ice bath
2. 2
   workup.STIRRINGThe reaction mixture is stirred for 1 h 30 min at a temperature of 0° C.
3. 3
   workup.ADDITIONIt is poured into ice
4. 4
   추출It is extracted with 3 volumes of ether
5. 5
   세척The organic phases are washed 3 times with 10% potassium carbonate solution
6. 6
   workup.ADDITIONby adding concentrated hydrochloric acid
7. 7
   기타The precipitate obtained
8. 8
   기타recrystallized

실험 절차

5 cm3 of ethylbenzene and 2.6 g of aluminum chloride are mixed with magnetic stirring in a 50-cm3 flask. The solution is cooled in an ice bath and 1 g of succinic anhydride is then added. The reaction mixture is stirred for 1 h 30 min at a temperature of 0° C. and then for 3 h at room temperature. It is poured into ice. The resulting mixture is acidified by adding 1N hydrochloric acid (pH 3-4). It is extracted with 3 volumes of ether. The organic phases are washed 3 times with 10% potassium carbonate solution. The aqueous phases are combined and acidified by adding concentrated hydrochloric acid. The precipitate obtained is drained and then recrystallized.

출처