반응 #2950

반응 방정식

N,N-diisopropyl-3-oxobutyramide

NaOH

phenyldiazonium chloride

→

title compound

수율 68.2%

N,N-Diisopropyl-2-phenylhydrazono-3-oxobutyramide

수율 68.2%

용매

water

반응 조건

후처리

1. 1
   기타as described in preparation 8
2. 2
   기타The crude reaction mixture
3. 3
   기타was purified by chromatography on silica gel (hexane/Et2O 95:5)

실험 절차

7.0 g (0.038 mol) of N,N-diisopropyl-3-oxobutyramide, a solution of 5.3 g (0.133 mol) of NaOH in 58 ml of water and 0.04 mol of phenyldiazonium chloride were treated as described in preparation 8. The crude reaction mixture was purified by chromatography on silica gel (hexane/Et2O 95:5) obtaining 7.5 g of the title compound which was used as such in the subsequent step. M.p.=143°-145° C.

출처