반응 #2947

반응 방정식

diketene acetone

dimethylamine

→

title compound

N,N-Dimethyl-3-oxobutyramide

용매

toluene

반응 조건

후처리

1. 1
   기타The solvent was removed in vacuo
2. 2
   기타the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

실험 절차

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

출처