반응 #2945

반응 방정식

diketene acetone

pyrrolidine

→

title compound

수율 97.9%

1-(3-Oxobutyryl)pyrrolidine

수율 97.9%

용매

toluene

반응 조건

후처리

1. 1
   기타as described in preparation 7
2. 2
   기타The solvent was removed in vacuo
3. 3
   기타the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%)

실험 절차

9 ml (0.05 mol) of diketene-acetone adduct and a solution of 4.2 ml (0.05 mol) of pyrrolidine in 20 ml of toluene were treated as described in preparation 7. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→1%) yielding 7.6 g of the title compound as a dark oil.

출처