반응 #2922

반응 방정식

2-acetylthiophene

n-Butyllithium

4,5-dimethylthiazole

→

title compound

1-(4,5-Dimethyl-2-thiazolyl)-1-(2-thienyl)ethanol

용매

diethyl ether

diethyl ether

반응 조건

후처리

1. 1
   workup.WAITAfter a further 1 hour the mixture was allowed

실험 절차

n-Butyllithium (2.5M solution in hexanes, 9.7 ml) was added dropwise to a stirred solution of 4,5-dimethylthiazole (2.5 g) in dry diethyl ether (30 ml) at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, 2-acetylthiophene (3.1 g) in diethyl ether (20 ml) was added dropwise. After a further 1 hour the mixture was allowed to warm to room temperature and was then worked up in the normal fashion to yield the title compound.

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