반응 #2904

반응 방정식

water

3-Bromofuran

n-butyllithium

5-acetyl-4-methylthiazole

→

1-(3-Furyl)-1-(4-methyl-5-thiazolyl)ethanol

용매

diethylether

diethylether

diethylether

반응 조건

후처리

1. 1
   workup.WAITAfter a further 3 hours at -70° C.
2. 2
   workup.WAITwas then left overnight
3. 3
   추출extracted with diethylether
4. 4
   기타The product thus obtained
5. 5
   기타was crystallised from diethylether, m.p. 102°-104° C.

실험 절차

3-Bromofuran (6.8 g) in diethylether (15 ml) was added dropwise to n-butyllithium (2.5M solution in hexane, 18.4 ml) in diethylether (20 ml) at -70° C. under a nitrogen atmosphere. After 1 hour, 5-acetyl-4-methylthiazole (5 g) in diethylether (15 ml) was added dropwise. After a further 3 hours at -70° C., the mixture was allowed to warm to room temperature and was then left overnight. The mixture was poured into water and extracted with diethylether. The product thus obtained was crystallised from diethylether, m.p. 102°-104° C.

출처