반응 #2900

반응 방정식

4-Methyl-5-thiazolecarbaldehyde

aluminium isopropoxide

sodium hydride

→

title compound

5-Methoxymethyl-4-methylthiazole

용매

dimethoxyethane

iodomethane

2-propanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   workup.DISTILLATIONDistillation

실험 절차

4-Methyl-5-thiazolecarbaldehyde (J. Amer. Chem. Soc., 1982, 104, 4934-4943) was reduced using aluminium isopropoxide in 2-propanol. The resulting alcohol was treated with sodium hydride in dimethoxyethane and iodomethane was added. Distillation gave the title compound.

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