반응 #2899

반응 방정식

1-Trifluoroacetylimidazole

4-methyl-2-trimethylsilyloxazole

Water

→

title compound

4-Methyl-2-trifluoroacetyloxazole

용매

diethyl ether

반응 조건

후처리

1. 1
   기타the organic layer was separated
2. 2
   세척washed
3. 3
   기타dried
4. 4
   기타evaporated

실험 절차

1-Trifluoroacetylimidazole (10 g) was added dropwise to 4-methyl-2-trimethylsilyloxazole (J. Chem. Soc., Chem. Commun., 1984, 258) (9.95 g) in diethyl ether (100 ml) at 0° C. under an atmosphere of dry nitrogen. The mixture was stirred overnight at room temperature. Water was added and the organic layer was separated, washed, dried and evaporated. Flash chromatography gave the title compound.

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