반응 #2898

반응 방정식

iodomethane

4-Bromo-3,5-dimethylpyrazole

sodium hydride

sodium hydrogen carbonate

hydrogen

→

title compound

4-Bromo-1,3,5-trimethylpyrazole

용매

dimethylformamide

dimethylformamide

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   기타evaporation under high vacuum
3. 3
   기타the residue was purified by column chromatography

실험 절차

4-Bromo-3,5-dimethylpyrazole (10 g) in dry dimethylformamide (50 ml) was added to a stirred suspension of sodium hydride (1.8 g) in dry dimethylformamide at 0° C. When the evolution of hydrogen was complete, iodomethane (8.9 g) was added dropwise. The mixture was allowed to warm to room temperature and after 30 minutes saturated aqueous sodium hydrogen carbonate (5 ml) was added. Following evaporation under high vacuum, the residue was purified by column chromatography to give the title compound.

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