반응 #2896

반응 방정식

Hydrochloric acid

3-Bromofuran

n-butyllithium

ethyl trifluoroacetate

→

title compound

3-Trifluoroacetylfuran

용매

diethyl ether

반응 조건

후처리

1. 1
   workup.WAITAfter a further 1 hour the mixture was allowed
2. 2
   workup.WAITwas then left
3. 3
   workup.STIRRINGthe mixture stirred for 5 minutes
4. 4
   기타The organic layer was separated
5. 5
   세척washed
6. 6
   기타dried
7. 7
   기타evaporated
8. 8
   workup.DISTILLATIONThe residue was distilled

실험 절차

3-Bromofuran (20 g) was added to a solution of n-butyllithium (2.5M in hexanes, 60 ml) in diethyl ether (200 ml) at -70° C. After 30 minutes, ethyl trifluoroacetate (28.6 g) was added slowly. After a further 1 hour the mixture was allowed to warm to room temperature and was then left to stir overnight. 1M Hydrochloric acid (100 ml) was added and the mixture stirred for 5 minutes. The organic layer was separated, washed, dried and evaporated. The residue was distilled to give the title compound. B.p. 118° C.

출처