반응 #2894

반응 방정식

n-Butyllithium

4-methylthiazole

trimethylsilylchloride

→

title compound

4-Methyl-2-trimethylsilylthiazole

용매

diethyl ether

반응 조건

후처리

1. 1
   기타was then quenched by the addition of saturated aqueous sodium hydrogen carbonate
2. 2
   workup.DISTILLATIONWork-up in the normal fashion and vacuum distillation

실험 절차

n-Butyllithium (2.5M solution in hexane, 1.1 equivalents) was added dropwise to a solution of 4-methylthiazole (1.0 equivalent) in dry diethyl ether at -70° C. under an atmosphere of dry nitrogen. After 30 minutes, trimethylsilylchloride (1.0 equivalent) was added dropwise. The mixture was allowed to warm to room temperature and was then quenched by the addition of saturated aqueous sodium hydrogen carbonate. Work-up in the normal fashion and vacuum distillation then gave the title compound. B.p. 42° C. at 1 mmHg.

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