반응 #2892

반응 방정식

sodium hydroxide

3-Chloropentane-2,4-dione

propionamide

propionic acid

→

5-Acetyl-2-ethyl-4-methyloxazole

반응 조건

후처리

1. 1
   추출extracted with dichloromethane
2. 2
   세척The combined extracts were washed with brine
3. 3
   기타dried
4. 4
   기타the solvent removed
5. 5
   기타to leave a brown oil which
6. 6
   workup.DISTILLATIONwas purified by vacuum distillation, b.p. 70° C. at 2 mbar

실험 절차

3-Chloropentane-2,4-dione (46.5 g), propionamide (50 g) and propionic acid (151 g) were heated at 145° C. for 5 hours. The mixture was cooled to room temperature, then basified to pH 10 using 10M aqueous sodium hydroxide, and extracted with dichloromethane. The combined extracts were washed with brine, dried and the solvent removed to leave a brown oil which was purified by vacuum distillation, b.p. 70° C. at 2 mbar.

출처