반응 #2888

반응 방정식

hydrochloric acid ethanol

4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-1H-imidazole

→

4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride

수율 189.2%

용매

ethanol

반응 조건

후처리

1. 1
   workup.WAITAfter a few minutes
2. 2
   여과is filtered
3. 3
   세척washed with cold ethanol
4. 4
   기타dried

실험 절차

2.5 ml of an 8.4N hydrochloric acid/ethanol solution are added to a solution, cooled in an ice bath, of 7.4 g (20.3 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)butyl]-1H-imidazole in 15 ml of absolute ethanol. After a few minutes, a precipitate appears which is filtered, washed with cold ethanol and dried, 7.7 g (19.2 mmol) of 4,5-dichloro-2-methyl-1-[4-(4-phenyl-1,2,3,6-tetrahydro-1-pyridyl)-butyl]-1H-imidazole hydrochloride being obtained.

출처