반응 #2878

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4-bromoaniline

cinnamoyl chloride

→

title compound

2-Chloro-6-bromoquinoline

6-bromo-1H-quinolin-2-one

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실험 절차

The title compound is prepared from 4-bromoaniline and cinnamoyl chloride according to the procedure described in J. Chem. Soc., Perkin Trans. I, 1972, 1648. The crude 6-bromo-1H-quinolin-2-one intermediate obtained is triturated in Et2O/hexanes and filtered to give a beige solid which is used directly in the chlorination step. The crude product is recrystallized in MeOH to afford the title compound as a beige solid.

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