반응 #2848

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N-methyl piperidine

3-[3-(S)-(4,6-dichlorobenzo[b]thiophene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine trifluoroacetate

trichloroethyl chloroformate

→

title compound

수율 75.0%

([3-[3-(S)-(4,6-Dichlorobenzo[b]thiophene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-phenyl]-iminomethyl)-carbamic acid 2,2.2-trichloroethyl ester

수율 75.0%

용매

CH2Cl2 DMF

EtOAc

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후처리

1. 1
   세척The organic layer is washed with 1N HCl, H2O, saturated NaCl
2. 2
   건조The organic layer is dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated
5. 5
   기타The residue is purified by column chromatography
6. 6
   세척eluting with a gradient of 1% MeOH/CH2Cl2 to 3% MeOH/CH2Cl2

실험 절차

To a solution of 3-[3-(S)-(4,6-dichlorobenzo[b]thiophene-2-sulfonylamino)-2-oxo-pyrrolidin-1-ylmethyl]-benzamidine trifluoroacetate (0.25 g, 0.40 mmol), prepared as in EXAMPLE 14, Part E, in 4 mL of CH2Cl2 :DMF (10:1) is added N-methyl piperidine (0.12 g, 1.2 mmol) followed by trichloroethyl chloroformate (0.93 g, 0.44 mmol). The solution is stirred for 16 h. After this time, the solution is diluted with EtOAc. The organic layer is washed with 1N HCl, H2O, saturated NaCl. The organic layer is dried over MgSO4, filtered and concentrated. The residue is purified by column chromatography eluting with a gradient of 1% MeOH/CH2Cl2 to 3% MeOH/CH2Cl2 to afford the title compound (0.20 g, 0.30 mmol) as a white solid.

출처