반응 #2842

반응 방정식

triethylamine

3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride

benzo[b]thiophene-2-sulfonyl chloride

→

title compound

수율 79.0%

Benzo[b]thiophene-2-sulfonic acid [1-(3-cyanobenzyl)-2-oxo-pyrrolidin-3-(S)-yl]-amide

수율 79.0%

용매

EtOAc

CH2Cl2

반응 조건

후처리

1. 1
   세척The solution is washed with 1N HCl, saturated NaHCO3, and saturated NaCl
2. 2
   건조The organic layer is dried over MgSO4
3. 3
   여과filtered
4. 4
   농축concentrated

실험 절차

To a solution of 3-(3-(S)-amino-2-oxo-pyrrolidin-1-ylmethyl)-benzonitrile hydrochloride (0.36 g, 1.43 mmol) in 15 mL of CH2Cl2 is added benzo[b]thiophene-2-sulfonyl chloride (0.32 g, 1.38 mmol). To the resulting solution is added triethylamine (0.29 g, 2.88 mmol). After 16 h, the solution is diluted with EtOAc. The solution is washed with 1N HCl, saturated NaHCO3, and saturated NaCl. The organic layer is dried over MgSO4, filtered and concentrated. The title compound (0.45 g, 1.09 mmol) is obtained as white solid.

출처