반응 #2829

반응 방정식

compound ( [5]-(54)-75 )

4-hexyl-3-nitrobenzoic acid morpholide

hydrazine monohydrate

→

compound ( [5]-(55)-75 )

수율 99.4%

3-amino-4-hexylbenzoic acid morpholide

수율 99.4%

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added
2. 2
   여과the solution was filtered through celite 545
3. 3
   기타to remove the catalyst
4. 4
   기타The solvent was evaporated under reduced pressure
5. 5
   기타The residue was purified by silica gel column chromatography (Kieselgel 60=20 g, ethyl acetate)

실험 절차

The compound ([5]-(54)-75) (700 mg) prepared in Example 62 was dissolved in ethanol (35 ml). After the solution was heated to 50° C., a suspension of 10% Pd/C (70 mg) in ethanol was added, and hydrazine monohydrate (0.35 ml) was added to the solution. The solution was stirred at 50° C. for 30 minutes. After the reaction was completed, the solution was filtered through celite 545 to remove the catalyst. The solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (Kieselgel 60=20 g, ethyl acetate) to obtain the above-captioned compound ([5]-(55)-75) (631 mg) as colorless oil.

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