반응 #2799

반응 방정식

chloroacetyl chloride

N-methylmorpholine

morpholine

→

chloroacetic acid morpholine carboxamide

용매

dichloromethane

반응 조건

후처리

1. 1
   온도Cool in an ice-bath
2. 2
   추출Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
3. 3
   건조Dry the organic layer over Na2SO4
4. 4
   여과filter
5. 5
   기타evaporate in vacuo

실험 절차

Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to obtain chloroacetic acid morpholine carboxamide.

출처