반응 #2777

ord-989c68d91dfc4d74a9b62cfdff0165f9

반응 방정식

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O
biotin-N-hydroxysuccinimide
NCCc1ccc(O)cc1
tyramine
CC[NH+](CC)CC.O=C([O-])O
triethylammonium bicarbonate
→
NCCc1ccc(O)cc1.O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21
biotin tyramine

반응물

O=C(O)CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@@H]21.O=C1CCC(=O)N1O
biotin-N-hydroxysuccinimide
NCCc1ccc(O)cc1
tyramine
CC[NH+](CC)CC.O=C([O-])O
triethylammonium bicarbonate

시약

없음

용매

CN(C)C=O
dimethylformamide

반응 조건

온도
50°CELSIUS
상세 조건
See reaction.notes.procedure_details.

실험 절차

a solution of biotin-N-hydroxysuccinimide, 170 mg (0.5 mMoles), and tyramine (recrystallized from water), 68.5 mg (0.5 mMoles), in 25 ml dimethylformamide was treated with 10 ml of 1M triethylammonium bicarbonate, pH 7.5, and then heated at 50° C. for 3 hours.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US05731158uspto-grants-1998_03