반응 #2670

반응 방정식

water

diphenyl diazomethane

acid

[3-fluoro-4,5-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-hydroxy-acetic acid

→

Diphenylmethyl [3-fluoro-4,5-bis-[(2-methoxy-ethoxy)-methoxy]-phenyl]-hydroxy-acetate

용매

ether

dichloromethane

반응 조건

후처리

1. 1
   기타by decanting
2. 2
   세척Washing with a saturated solution of sodium bicarbonate
3. 3
   기타drying
4. 4
   기타evaporating the solvents
5. 5
   기타yielded after chromatography on silica
6. 6
   세척eluting with an ethyl acetate

실험 절차

5.3 g of the acid of Step A were dissolved in 66 ml of dichloromethane and then 46 ml of a solution of diphenyl diazomethane at 6.5 g in ether were added at 15° C. The mixture was stirred for 16 hours at ambient temperature and then water was added, followed by decanting and acidifying with acetic acid. Washing with a saturated solution of sodium bicarbonate, drying and evaporating the solvents yielded after chromatography on silica and eluting with an ethyl acetate--hexane mixture (50--50) 4.0 g of the desired product with a Rf=0.17.

출처