반응 #2617

반응 방정식

N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-(N-hydroxyimino)-N-(2-methoxyphenyl)benzenesulfonamide

hydrogen chloride ether

→

title compound

수율 99.8%

N-{2-[4-{4-Fluorobenzoyl)piperidino]ethyl}-4-(N-hydroxyimino)-N-(2-methoxyphenyl)benzenesulfonamide hydrochloride

수율 99.8%

용매

methylene chloride

반응 조건

후처리

1. 1
   기타the solvent was removed by evaporation
2. 2
   여과collected by filtration

실험 절차

N-{2-[4-(4-fluorobenzoyl)piperidino]ethyl}-4-(N-hydroxyimino)-N-(2-methoxyphenyl)benzenesulfonamide (65 mg, 0.12 mmol) was dissolved in methylene chloride (2 ml) to which was subsequently added saturated hydrogen chloride/ether solution (1 ml). After 5 minutes of stirring, the solvent was removed by evaporation, and the resulting residue was solidified in ether (5 ml) and collected by filtration to obtain 69 mg (99.8%) of the title compound in a colorless amorphous powder form.

출처