반응 #2551

반응 방정식

4-Chloromethyl-N-(2-methoxyphenyl)benzamide

methylamine

→

title compound

수율 100.0%

N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

수율 100.0%

용매

dioxane

dioxane

반응 조건

후처리

1. 1
   기타was removed by evaporation
2. 2
   workup.ADDITIONthe resulting residue was diluted with methylene chloride (10 ml)
3. 3
   건조After drying on anhydrous sodium carbonate
4. 4
   기타the solvent was removed by evaporation

실험 절차

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

출처