반응 #2507833

반응 방정식

6,8-Difluoro-3-[2-(6-fluoro-3-pentylchroman-7-yl)vinyl]-2H-chromene

→

6,8-Difluoro-3-[2-(6-fluoro-3-pentylchroman-7-yl)ethyl]-2H-chromene

용매

THF

반응 조건

후처리

1. 1
   여과The catalyst is filtered off
2. 2
   기타the solution is evaporated
3. 3
   여과the residue is filtered through silica gel with toluene/heptane (3:2)
4. 4
   기타the crude product is recrystallised from n-heptane at −25° C.
5. 5
   기타giving colourless crystals of m.p. 84° C.

실험 절차

6,8-Difluoro-3-[2-(6-fluoro-3-pentylchroman-7-yl)vinyl]-2H-chromene is dissolved in THF and hydrogenated to completion on a palladium/active carbon catalyst. The catalyst is filtered off, the solution is evaporated, the residue is filtered through silica gel with toluene/heptane (3:2), and the crude product is recrystallised from n-heptane at −25° C., giving colourless crystals of m.p. 84° C.

출처