반응 #2507829

반응 방정식

6-fluoro-3-pentylchroman-7-carbaldehyde

sodium borohydride

→

(6-fluoro-3-pentylchroman-7-yl)methanol

용매

water

ethanol

반응 조건

후처리

1. 1
   추출extracted three times with MTB ether
2. 2
   세척phases are washed with sat. sodium chloride soln
3. 3
   건조and dried over sodium sulfate
4. 4
   기타the solvent is removed in vacuo
5. 5
   여과the residue is filtered through silica gel with dichloromethane (Rf=0.3)

실험 절차

11.1 g (44.3 mmol) of 6-fluoro-3-pentylchroman-7-carbaldehyde are dissolved in 100 ml of ethanol, and 2.0 g (52.8 mmol) of sodium borohydride are added in portions. After 3 h, the batch is diluted with water and extracted three times with MTB ether. The combined org. phases are washed with sat. sodium chloride soln. and dried over sodium sulfate, the solvent is removed in vacuo, and the residue is filtered through silica gel with dichloromethane (Rf=0.3), giving (6-fluoro-3-pentylchroman-7-yl)methanol as a colourless solid.

출처