반응 #2499185

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[4-bromo-2-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone

1-methylimidazolidin-2-one

→

title compound

수율 65.4%

1-[4-[4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine-1-carbonyl]-3-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl]-3-methylimidazolidin-2-one

수율 65.4%

반응 조건

실험 절차

Using [4-bromo-2-(1,1-dioxo-1λ6-isothiazolidin-2-yl)phenyl][4-(5-cyclopropyl-3-methylpyridin-2-yl)piperazin-1-yl]methanone (205 mg) described in Preparation Example 240 and 1-methylimidazolidin-2-one (59 mg) and by the reaction and treatment in the same manner as in Example 536, the title compound (139 mg) was obtained.

출처