반응 #2495313

반응 방정식

8,8-dimethyl-6-(3-morpholin-4-yl-phenyl)-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carbonitrile

sodium hydroxide

ethanol

hydrochloric acid

→

8,8-dimethyl-6-(3-morpholin-4-yl-phenyl)-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carboxylic acid

수율 90.0%

용매

water

반응 조건

후처리

1. 1
   추출extracted with ethyl acetate (2×100 mL)
2. 2
   세척washed with water
3. 3
   건조dried over anhydrous sodium sulfate
4. 4
   농축concentrated in vacuo

실험 절차

To a stirred mixture solution of 8,8-dimethyl-6-(3-morpholin-4-yl-phenyl)-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carbonitrile (698.0 mg, 2.0 mmol) in ethanol (10.0 mL) was added 50% sodium hydroxide in water (8.5 mL). The reaction mixture was stirred at 90° C. for 6 h. The mixture was neutralized with a 3 N aqueous hydrochloric acid solution and extracted with ethyl acetate (2×100 mL), washed with water, dried over anhydrous sodium sulfate and then concentrated in vacuo to afford 8,8-dimethyl-6-(3-morpholin-4-yl-phenyl)-5,6,7,8-tetrahydro-[1,5]naphthyridine-2-carboxylic acid (660.6 mg, 90%) as a light white solid which was used for next step without further purification: MS (ESI) M+1=368.1.

출처