반응 #2490309
ord-2968d08bd1cc41e0b2159cacf69410b1
반응 방정식
didecyldimethylammonium chloride
naproxen sodium salt
→
didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate
수율 95.0%
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출The product was extracted by ethyl acetate and organic phase
- 2기타was separated
- 3세척washed with distilled water
- 4기타Ethyl acetate phase was removed
- 5기타solvent evaporated
실험 절차
The stoichiometric mixture (0.025 mol) of didecyldimethylammonium chloride and naproxen sodium salt were dissolved in distilled water and stirred at room temperature for 1 h. The product was extracted by ethyl acetate and organic phase was separated and then washed with distilled water. Ethyl acetate phase was removed and solvent evaporated. The product, didecyldimethylammonium (S)-6-methoxy-α-methyl-2-naphthaleneacetate (95% yield), was dried under vacuum. The product is soluble in chloroform, acetone, and DMSO. It lacks miscibility with water and hexane. Thermogravimetric analysis: Tonset5%=156° C., and Tonset=190° C. 1H and 13C NMR (DMSO) were obtained.