반응 #2488128

ord-1c2b49066e724a5da9a64b38bf415bb7

반응 방정식

O=C1NC(=O)/C(=C/c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2F)S1
(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-4-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine
CC(C)(C)OC(=O)CBr
tert-butyl bromoacetate
→
O=C(O)CN1C(=O)S/C(=C\c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2F)C1=O
[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-4-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid

반응물

O=C1NC(=O)/C(=C/c2ccc3c(cnn3Cc3ccc(Cl)cc3C(F)(F)F)c2F)S1
(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-4-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine
CC(C)(C)OC(=O)CBr
tert-butyl bromoacetate

시약

없음

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

[(5Z)-5-({1-[4-Chloro-2-(trifluoromethyl)benzyl]-4-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidin-3-yl]acetic acid was prepared from [(5Z)-5-({1-[4-chloro-2-(trifluoromethyl)benzyl]-4-fluoro-1H-indazol-5-yl}methylidene)-2,4-dioxo-1,3-thiazolidine and tert-butyl bromoacetate following General Procedure I.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08796256B2uspto-grants-2014_08