반응 #2487475

반응 방정식

ethyl 5-(6-chloro-5-methoxy-2-phenylindol-1-ylmethyl)furan-2-carboxylate

ammonia

→

title compound

5-(6-Chloro-5-methoxy-2-phenylindol-1-ylmethyl)furan-2-carboxamide

반응 조건

후처리

1. 1
   여과The reaction mixture was filtered
2. 2
   세척washed with methanol
3. 3
   농축concentrated under reduced pressure

실험 절차

A suspension of ethyl 5-(6-chloro-5-methoxy-2-phenylindol-1-ylmethyl)furan-2-carboxylate (258 mg) in ammonia (Ca. 7 mol/L methanol solution, 12.4 mL) was stirred at room temperature for 44 hours. The reaction mixture was filtered, washed with methanol, and then concentrated under reduced pressure to obtain the title compound (138 mg). 1H-NMR (CDCl3) δ ppm: 3.95 (3H, s), 5.23 (2H, s), 6.10 (1H, d, J=3.5 Hz), 6.50-6.55 (1H, m), 7.03 (1H, d, J=3.5 Hz), 7.15 (1H, s), 7.35-7.55 (6H, m).

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