반응 #2487444

반응 방정식

N-thionylaniline

3-fluoro-O-phenylene diamine

→

4-fluoro-2,1,3-benzothiadiazole

반응 조건

후처리

1. 1
   기타4-Fluoro-2,1,3-benzothiadiazole was synthesized
2. 2
   여과After the solvent was filtered off
3. 3
   workup.DISSOLUTIONthe residue was dissolved in dichloromethane
4. 4
   세척the solution was washed with 10% HCl solution and water
5. 5
   기타The organic layer was dried
6. 6
   기타evaporated to dryness
7. 7
   기타Purification by chromatography on a silica gel column with chloroform as an eluent

실험 절차

4-Fluoro-2,1,3-benzothiadiazole was synthesized according to the method in which N-thionylaniline (0.49 g, 3.5 mmol) was added to a solution of the 3-fluoro-O-phenylene diamine (200 mg, 1.6 mmol) in foluen (2 ml) The reaction mixture was heated at 100-120° C. for 4 hr. After the solvent was filtered off, the residue was dissolved in dichloromethane and the solution was washed with 10% HCl solution and water, successively. The organic layer was dried and evaporated to dryness. Purification by chromatography on a silica gel column with chloroform as an eluent gave 4-fluoro-2,1,3-benzothiadiazole as pal yellow oil. Confirmed data of the obtained chemical compound is shown as follows.

출처