반응 #2477112

반응 방정식

lithium aluminum hydride

ethyl 2-ethyl-8-methylfuro[3,2-c]pyrazolo[1,5-a]pyridine-1-carboxylate

Sodium sulfate decahydrate

→

title compound

수율 124.1%

(2-ethyl-8-methylfuro[3,2-c]pyrazolo[1,5-a]pyridin-1-yl)methanol

수율 124.1%

용매

tetrahydrofuran

tetrahydrofuran

반응 조건

후처리

1. 1
   온도cooling
2. 2
   온도cooling
3. 3
   여과the insoluble material was filtered off
4. 4
   농축The filtrate was concentrated under reduced pressure
5. 5
   세척the residue was washed with diisopropyl ether

실험 절차

To a suspension of 80% lithium aluminum hydride (293 mg, 7.91 mmol) in tetrahydrofuran (16 mL) was added a solution of ethyl 2-ethyl-8-methylfuro[3,2-c]pyrazolo[1,5-a]pyridine-1-carboxylate (430 mg, 1.26 mmol) in tetrahydrofuran (16 mL) under ice-cooling, and the mixture was stirred at room temperature for 30 min. Sodium sulfate decahydrate (4.3 g) was added under ice-cooling, and the insoluble material was filtered off. The filtrate was concentrated under reduced pressure, and the residue was washed with diisopropyl ether to give the title compound (360 mg, yield 99%).

출처