반응 #2474132

반응 방정식

2-(2-oxopropyl)benzoic acid

4-methoxyaniline

1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride

pyridine

→

compound

수율 44.4%

2-(4-methoxyphenyl)-3-methyl-1(2H)-isoquinolinone

수율 44.4%

용매

Chloroform

chloroform

반응 조건

후처리

1. 1
   세척the organic phase was washed by aqueous citric acid solution, sodium hydrogen carbonate aqueous solution and saturated brine in that order
2. 2
   건조dried with anhydrous sodium sulfate
3. 3
   기타The product was purified by silica gel column chromatography (hexane/ethyl acetate=10/0-3/7)

실험 절차

2-(2-oxopropyl)benzoic acid (100 mg, 0.56 mmol), 4-methoxyaniline (76 mg, 0.56 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (0.84 mmol) and pyridine (0.5 mL) were dissolved in chloroform (5 mL) and stirred at room temperature overnight. Chloroform was added, the organic phase was washed by aqueous citric acid solution, sodium hydrogen carbonate aqueous solution and saturated brine in that order, and dried with anhydrous sodium sulfate. The product was purified by silica gel column chromatography (hexane/ethyl acetate=10/0-3/7) to obtain the target compound (66 mg, 44%) as a light brown solid.

출처