반응 #2471752

반응 방정식

4-hydroxy-1-naphtaldehyde

4-(dicyanomethylene)-2,6-dimethyl-4H-pyrane

piperidine

→

desired compound

수율 48.2%

((E)-2-(2-(4-hydroxynaphthalene-1-yl)vinyl)-6-methyl-4H-pyrane-4-ylidene)malononitrile

수율 48.2%

용매

ethanol

반응 조건

후처리

1. 1
   온도The resultant was heated
2. 2
   온도refluxed under an argon atmosphere for 6 hours
3. 3
   기타the solvent was removed under reduced pressure
4. 4
   기타followed by purification by column chromatography (SiO2, CHCl3:MeOH=10:1 (v/v))

실험 절차

4-hydroxy-1-naphtaldehyde (0.70 g (5.81 mmol)), 4-(dicyanomethylene)-2,6-dimethyl-4H-pyrane (1.0 g (5.81 mmol)), piperidine (0.50 g (5.81 mmol)), and ethanol (50 mL) were added to a 50-mL three-neck flask. The resultant was heated and refluxed under an argon atmosphere for 6 hours and then the solvent was removed under reduced pressure, followed by purification by column chromatography (SiO2, CHCl3:MeOH=10:1 (v/v)). Thus a desired compound was obtained (yield: 48.2%).

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