반응 #2468009

반응 방정식

2,4-dichloro-5-dimethylamino-pyrimidine

4,5,6,7-tetrahydroimidazopyridine dihydrochloride

4,5,6,7-tetrahydroimidazopyridine dihydrochloride

potassium carbonate

potassium carbonate

→

2-chloro-4-(3,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-5-dimethylamino-pyrimidine

용매

water

isopropanol

반응 조건

후처리

1. 1
   workup.STIRRINGstirred for 1 h
2. 2
   기타The precipitate formed
3. 3
   여과filtered
4. 4
   세척washed
5. 5
   기타dried

실험 절차

5 g of 2,4-dichloro-5-dimethylamino-pyrimidine are dissolved in 30 mL isopropanol and combined with 5.82 g 4,5,6,7-tetrahydroimidazopyridine dihydrochloride and 6.06 g potassium carbonate. After 6 and 8 days in each case 1 g of 4,5,6,7-tetrahydroimidazopyridine dihydrochloride and 1 g potassium carbonate are added. In all, the mixture is stirred for 10 days at 25° C. The reaction mixture is diluted with 400 mL water and stirred for 1 h. The precipitate formed is suction filtered, washed and dried.

출처