반응 #2468008

반응 방정식

2,4-dichloro-5-methoxy-pyrimidine

4,5,6,7-tetrahydroimidazopyridine dihydrochloride

ethyldiisopropylamine

→

2-chloro-4-(3,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl)-5-methoxy-pyrimidine

용매

butanol

반응 조건

후처리

1. 1
   기타The crude mixture is purified by column chromatography
2. 2
   workup.ADDITION0.2% formic acid is added to both eluants
3. 3
   기타The suitable fractions are freeze-dried

실험 절차

1 g 2,4-dichloro-5-methoxy-pyrimidine are dissolved in 4 mL butanol and combined with 1.04 g 4,5,6,7-tetrahydroimidazopyridine dihydrochloride and 2.96 mL ethyldiisopropylamine. This mixture is stirred for 16 h at 50° C. and then the solvent is eliminated in vacuo. The crude mixture is purified by column chromatography. The carrier material used is C18-RP-silica gel and a gradient is run through which consists at the starting point of 95% water and 5% acetonitrile and at the finishing point of 70% water and 30% acetonitrile. 0.2% formic acid is added to both eluants. The suitable fractions are freeze-dried.

출처