반응 #2468005

반응 방정식

2-(1-trityl-1H-imidazol-4-yl)-propylamine

formaldehyde

→

7-methyl-3a.4,5,6,7.7a-hexahydro-1H-imidazo[4,5-c]pyridine

용매

HCl

반응 조건

후처리

1. 1
   온도After 5 h it is cooled to RT
2. 2
   여과suction filtered
3. 3
   기타to remove the precipitate
4. 4
   기타formed

실험 절차

3.2 g 2-(1-trityl-1H-imidazol-4-yl)-propylamine is suspended in aqueous HCl (1 N). After the addition of 2.9 mL formaldehyde the mixture is heated to 95° C. with stirring. After 5 h it is cooled to RT, suction filtered to remove the precipitate formed and the solvent is eliminated in vacuo. This crude product is used in the following reaction step without further purification.

출처