반응 #2468002

ord-27600ec5354142cdb571a44664f174fa

반응 방정식

CCN(CC)CC
triethylamine
ClC(c1ccccc1)(c1ccccc1)c1ccccc1
chlorotriphenylmethane
N#CCc1c[nH]cn1
(1H-imidazol-4-yl)-acetonitrile
O
Water
N#CCc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1
(1-trityl-1H-imidazol-4-yl)-acetonitrile

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타the organic phase is separated off
  2. 2
    건조dried with MgSO4

실험 절차

2.5 g (1H-imidazol-4-yl)-acetonitrile are dissolved in 20 mL DMF. After the addition of 3.6 mL triethylamine and 7.25 g chlorotriphenylmethane the suspension is left for 60 h at RT with stirring. Water and ethyl acetate are added, the organic phase is separated off, dried with MgSO4 and the solvent is eliminated in vacuo.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08258129B2uspto-grants-2012_09