반응 #2468000

반응 방정식

(S)-1-bromomethyl-2-(3H-imidazol-4-yl)-ethylamine

sodium acetate

→

(R)-2-(3H-imidazol-4-yl)-1-methyl-ethylamine

용매

acetic acid

반응 조건

후처리

1. 1
   여과After the catalyst has been filtered off the solvent
2. 2
   기타the crude product is used without further purification in the following reaction step

실험 절차

1.5 g (S)-1-bromomethyl-2-(3H-imidazol-4-yl)-ethylamine and 1.87 g sodium acetate are dissolved in 94 mL acetic acid (10%). After the addition of 400 mg palladium/C the suspension is shaken under 3.5 bar H2 pressure at RT for about 60 h. After the catalyst has been filtered off the solvent is eliminated in vacuo and the crude product is used without further purification in the following reaction step.

출처