반응 #2467999
ord-f31c1ac2e5a84deb8146f72f9c708390
반응 방정식
(S)-histidinol
HBr
→
(S)-1-bromomethyl-2-(3H-imidazol-4-yl)-ethylamine
반응 조건
온도
110°CELSIUS
상세 조건
See reaction.notes.procedure_details.
실험 절차
900 mg (S)-histidinol (×2HCl) are dissolved in 20 mL HBr in acetic acid (32%) and heated to 110° C. in the microwave for 6 h. The solvent is eliminated in vacuo, the residue is dissolved in ethanol and again freed from the solvent in vacuo. This crude product is used in the next reaction step without further purification.