반응 #2467994

반응 방정식

3-amino-5-phenylthiophene-2-carbonitrile

ethanol

→

solid

수율 45.0%

3-Amino-5-phenylthiophene-2-carboxamide

수율 45.0%

용매

sodium hydroxide

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 1 h
2. 2
   기타to attain rt
3. 3
   기타the crystals separated
4. 4
   여과were filtered off
5. 5
   세척washed with cold water
6. 6
   기타dried

실험 절차

To a suspension of 3-amino-5-phenylthiophene-2-carbonitrile (150 mg) in aqueous sodium hydroxide solution (20 mL, 10%) was added ethanol (10 mL) and the mixture was refluxed for 1 h. The reaction mixture was allowed to attain rt and the crystals separated were filtered off, washed with cold water and dried to give the product as a golden yellow color solid (70 mg, 45%), mp 180-182° C.

출처