반응 #2467985

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Methyl 4-aminothiophene-3-carboxylate hydrochloride

ammonia

→

oil

수율 65.0%

Methyl 4-aminothiophene-3-carboxylate

수율 65.0%

용매

water

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후처리

1. 1
   추출The solution was extracted with chloroform
2. 2
   세척the combined chloroform layer was washed with water, brine
3. 3
   건조dried over sodium sulfate
4. 4
   여과The solution was filtered
5. 5
   기타evaporated the solvent

실험 절차

Methyl 4-aminothiophene-3-carboxylate hydrochloride (290 mg) was dissolved in water (20 mL) and basified with ammonia solution. The solution was extracted with chloroform and the combined chloroform layer was washed with water, brine and dried over sodium sulfate. The solution was filtered and evaporated the solvent to give the product as pale yellow color oil (150 mg, 65%). 1H NMR (400 MHz, CDCl3): δ 7.92 (1H, d, J=3.6 Hz), 6.08 (1H, d, J=3.6 Hz), 4.79 (2H, br s), 3.85 (3H, s).

출처