반응 #2467984

반응 방정식

4-oxo-3-methoxycarbonyltetrahydrothiophene

hydroxylamine hydrochloride

→

title compound

수율 62.3%

Methyl 4-aminothiophene-3-carboxylate hydrochloride

수율 62.3%

용매

acetonitrile

반응 조건

후처리

1. 1
   온도under reflux for 1 h
2. 2
   온도The mixture was then cooled
3. 3
   기타the solid which separated
4. 4
   여과was filtered off
5. 5
   세척washed with dry ether

실험 절차

A mixture of 4-oxo-3-methoxycarbonyltetrahydrothiophene (6.5 g, 40.62 mmol), hydroxylamine hydrochloride (2.84 g, 40.62 mmol) and acetonitrile (30 mL) was stirred under reflux for 1 h. The mixture was then cooled and the solid which separated was filtered off and washed with dry ether to afford the title compound (4.9 g, 62%), mp 192-196° C.

출처