반응 #2467982

반응 방정식

acrylate

Methyl acrylate

methyl thioglycolate

piperidine

acrylate

piperidine

→

product

수율 100.0%

Methyl 3-[(methoxycarbonyl)methylthio]propanoate

수율 100.0%

용매

chloroform

반응 조건

후처리

1. 1
   세척The chloroform layer was washed with water, brine
2. 2
   건조dried over Na2SO4
3. 3
   여과The solution was filtered
4. 4
   기타evaporated the solvent

실험 절차

Methyl acrylate (4.25 g, 49.5 mmol) was added dropwise over 20 min to a stirred solution of methyl thioglycolate (5 g, 47.16 mmol) and piperidine (0.10 mL) at rt. When about half of the acrylate had been introduced, more piperidine (0.10 mL) was added. After completion of the addition of the acrylate, the reaction mixture was stirred for 1 h at rt. The mixture was diluted with 100 mL of chloroform. The chloroform layer was washed with water, brine and dried over Na2SO4. The solution was filtered and evaporated the solvent to give the product as an oil (9 g, 100%).

출처