반응 #2467945

반응 방정식

2-Oxo-3-phenyl-propionic acid

(4-Phenyl-thiazol-2-yl)-methylamine

NaBH3CN

→

product

수율 62.1%

3-Phenyl-2-[(4-phenyl-thiazol-2-ylmethyl)-amino]-propionic acid

수율 62.1%

용매

MeOH

반응 조건

후처리

1. 1
   기타The product was purified by HPLC

실험 절차

To a solution of 2-Oxo-3-phenyl-propionic acid (1.6 mmol, 264 mg) and (4-Phenyl-thiazol-2-yl)-methylamine (1.0 mmol, 190 mg) in MeOH (4 mL), is added NaBH3CN (2.0 mmol, 1N in THF). The pH was then adjusted at 6 with 1M HClaq. The mixture was stirred at room temperature for 3 days. The product was purified by HPLC to give the pure product (210 mg, 62%).

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