반응 #2467943

반응 방정식

2-benzylmalonic acid diethyl ester

KOH

→

final product

2-Benzyl-malonic acid monoethyl ester

용매

EtOH

EtOH

반응 조건

후처리

1. 1
   기타The solvent was removed under reduced pressure
2. 2
   workup.DISSOLUTIONthe resulting liquid dissolved in 5% NaHCO3 (30 mL)
3. 3
   세척washed with EtOAc (3×10 mL)
4. 4
   추출back extracted with 5% NaHCO3 (50 mL)
5. 5
   추출extracted with EtOAc
6. 6
   세척The organic layer was washed with H2O
7. 7
   건조dried with Na2SO4
8. 8
   기타The solvent was removed under reduced pressure

실험 절차

To a solution of 2-benzylmalonic acid diethyl ester 2.5 g (10 mmol) in EtOH (10 mL) was added 1N KOH in EtOH (8.5 mL). The solution was stirred for 1 h at room temperature. The solvent was removed under reduced pressure, and the resulting liquid dissolved in 5% NaHCO3 (30 mL), washed with EtOAc (3×10 mL), and back extracted with 5% NaHCO3 (50 mL). The combined NaHCO3 solutions were acidified to pH=3 with 1N HCl and extracted with EtOAc. The organic layer was washed with H2O, dried with Na2SO4. The solvent was removed under reduced pressure to give final product as oil, 1.4 g (74%).

출처