반응 #2467942

반응 방정식

3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid methyl ester

KOH

→

3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid

수율 83.7%

용매

ethanol

반응 조건

후처리

1. 1
   기타After the solvent was evaporated from the reaction mixture
2. 2
   workup.DISSOLUTIONthe residue was dissolved
3. 3
   workup.ADDITIONby adding water
4. 4
   기타The produced precipitates
5. 5
   여과were filtered with suction
6. 6
   세척washed with water

실험 절차

To a solution of 3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid methyl ester (74 mg, 0.2 mmol) dissolved in ethanol (4 mL) was added 1N—KOH (0.5 mL, 0.5 mmol) and the mixture was stirred at room temperature for 2 hours. After the solvent was evaporated from the reaction mixture, the residue was dissolved by adding water and acidified (H=2) with 2N—HCl under ice cooling. The produced precipitates were filtered with suction, washed with water to afford 59 mg (yield 80%) of the desired 3-Phenyl-2-[(4-phenyl-thiazole-2-carbonyl)-amino]-propionic acid as white solids.

출처