반응 #2467920
ord-f53d919e2e6047bf8a7481d8565fcec9
반응 방정식
z,z,z-octadeca-6,9,12-trienoyl chloride
pyridoxine hydrochloride
triethylamine
→
2-methyl-3-hydroxy-4,5-di(z,z,z-octadeca-6,9,12-trienoyloxy)methyl pyridine
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타(4 h)
- 2농축was concentrated
- 3기타purified by flash chromatography (ethyl acetate/hexane)
실험 절차
A solution of z,z,z-octadeca-6,9,12-trienoyl chloride (650 mg, 2.2 mmol) in methylene chloride (10 ml) was added slowly dropwise to a mixture of pyridoxine hydrochloride (206 mg, 1 mmol), triethylamine (0.7 ml, 5 mmol) and 4-(N,N-dimethylamino)pyridine (few mg, catalytic amount) in methylene chloride (20 ml) at 0° C. under nitrogen. On completion, as indicated by tic, (4 h) the mixture was concentrated and purified by flash chromatography (ethyl acetate/hexane), yielding 2-methyl-3-hydroxy-4,5-di(z,z,z-octadeca-6,9,12-trienoyloxy)methyl pyridine as a colourless oil.