반응 #2452

반응 방정식

p-bromo anisole

acrylic acid

triethyamine

→

p-methoxy cinnamic acid

수율 81.2%

용매

water

water

반응 조건

후처리

1. 1
   기타recovered by phase separation from a previous run)
2. 2
   workup.ADDITIONwere charged into an autoclave

실험 절차

p-bromo anisole (8.4 g), acrylic acid (3.9 g), water (13.5 g), PdCl2 (0.3 mg) and triethyamine (14.3 g, 89.3% pure by titration, the balance being water, recovered by phase separation from a previous run) were charged into an autoclave and heated for 2 hours at 130° C. The work up detailed in Example 1 gave 6.5 g (81%) of >98% pure p-methoxy cinnamic acid.

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