반응 #2450861

반응 방정식

8-isopropyl-4-(N-methyl-N-phenylamino)-2-(methylsulfanyl)pyrazolo[1,5-a]-1,3,5-triazine

4-(pyridin-2-yl)benzylamine

→

8-isopropyl-2-(methylsulfanyl)-4-[4-(pyridin-2-yl)benzylamino]pyrazolo[1,5-a]-1,3,5-triazine

수율 60.0%

용매

EtOH

반응 조건

후처리

1. 1
   기타resulting in the preparation of the compound IIa.1

실험 절차

According to the same conditions resulting in the preparation of the compound IIa.1, the compound IIa.2 is prepared from 8-isopropyl-4-(N-methyl-N-phenylamino)-2-(methylsulfanyl)pyrazolo[1,5-a]-1,3,5-triazine and from 4-(pyridin-2-yl)benzylamine. Yield=60%. Mp=136-138° C. (EtOH). 1H NMR (300 MHz, CDCl3): δ 8.71 (d, 1H, J=4.7 Hz, Harom), 8.00 (d, 2H, J=8.1 Hz, Harom), 7.82-7.72 (m, 3H, Harom), 7.49 (d, 2H, J=8.1 Hz, Harom), 7.26 (dd, 1H, J=4.7 Hz, 7.2 Hz, Harom), 6.76 (bs, 1H, NH), 4.86 (d 2H, J=6.0 Hz, CH2), 3.16 (hept, 1H, J=7.0 Hz, CH), 2.57 (s, 3H, CH3), 1.33 (d, 6H, J=7.0 Hz, 2 CH3). MS (ESI): m/z 391 (MH+).

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